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Monoclonal antibody-based therapy of neuroblastoma

N K Cheung1, B H Kushner, K Kramer

  • 1Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. cheungn@mskcc.org

Hematology/Oncology Clinics of North America
|January 5, 2002
PubMed

The curative potential of mAbs in the treatment of patients with metastatic neuroblastoma is increasingly evident. The idiotype network appears to represent one component of a complex mechanism for success with mAb-based immunotherapy. Ongoing strategies to modify or reconstruct mAbs, to engage them with cytokines, or to unite them with T cells open new avenues for harnessing the unique forces of the immune system against some of the most deadly pediatric cancers.

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