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Interference of spironolactone in 11-doexycorticosterone radioassays
The Journal of Clinical Endocrinology and Metabolism
|October 1, 1975
Abstract:
Uniformly elevated plasma 11-deoxycorticosterone (DOC) values are obtained in patients receiving spironolactone. This elevation is shown to be spurious, and is a result of cross-interference of spironolactine and its metabolite, canrenone, in both the DOC radioimmunoassay and competitive protein-binding radioassay.
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