Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tocopherol in human platelets.

A Nordoy, E Strom

    Journal of Lipid Research
    |September 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Platelets concentrate more tocopherol (vitamin E) than red blood cells, but do not absorb additional vitamin E. Tocopherol treatment boosts vitamin E in plasma and red blood cells, not platelets.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Using electrical impedance tomography to estimate tidal volume in bottlenose dolphins and cape fur seals in seawater and on land.

    The Journal of experimental biology·2026
    Same author

    Single organ metastatic sites in non-small cell lung cancer: Patient characteristics, treatment patterns and outcomes from a large retrospective Canadian cohort.

    Lung cancer (Amsterdam, Netherlands)·2024
    Same author

    Functional outcome and alignment in computer-assisted and conventionally operated total knee replacements: a multicentre parallel-group randomised controlled trial.

    The bone & joint journal·2014
    Same author

    Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.

    Proceedings of the National Academy of Sciences of the United States of America·2008
    Same author

    [Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53].

    Molekuliarnaia biologiia·2007
    Same author

    Atorvastatin and omega-3 fatty acids protect against activation of the coagulation system in patients with combined hyperlipemia.

    Journal of thrombosis and haemostasis : JTH·2003
    Same journal

    Erratum to 'Stearoyl-CoA desaturase-1 is vital for milk lipid synthesis: Deletion impairs mammary gland and neonatal development' [Journal of Lipid Research 66/12 (2025) 100941].

    Journal of lipid research·2026
    Same journal

    The Metabolic-Immune Axis in MASH: Is the Macrophage Signature the Key to Liver Disease Staging?

    Journal of lipid research·2026
    Same journal

    BK channel deficiency promotes lipolysis via an AKT-independent activation of the cAMP/PKA/HSL pathway.

    Journal of lipid research·2026
    Same journal

    Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis.

    Journal of lipid research·2026
    Same journal

    LIPA regulates myeloid differentiation and is essential for intra-plaque macrophage accumulation during atherogenesis.

    Journal of lipid research·2026
    Same journal

    Hydrolysis and depletion of phosphatidylglycerol at peak murine acute lung injury.

    Journal of lipid research·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Hematology
    • Nutritional Science

    Background:

    • Tocopherol (vitamin E) is a crucial lipid-soluble antioxidant.
    • Understanding tocopherol distribution and uptake in blood components is vital for its physiological role.
    • Platelets and erythrocytes (red blood cells) are key blood cells with distinct metabolic functions.

    Purpose of the Study:

    • To quantify and compare total tocopherol levels in human platelets, plasma, and erythrocytes.
    • To investigate the in vitro uptake of tocopherol by these blood components.
    • To assess the impact of sustained tocopherol supplementation on tocopherol levels and platelet function.

    Main Methods:

    • Spectrophotometric analysis was employed to determine tocopherol concentrations.

    Related Experiment Videos

  • In vitro incubation experiments were conducted to study tocopherol uptake.
  • Platelet function and lipid metabolism were evaluated following tocopherol treatment.

    • Main Results:

    • Platelets exhibited approximately three times higher tocopherol content per cell than erythrocytes.
    • Erythrocytes and plasma showed significant tocopherol uptake in vitro, while platelets did not.
    • Three months of tocopherol supplementation increased tocopherol in plasma and erythrocytes but not in platelets.
    • Tocopherol treatment did not adversely affect platelet function or lipid metabolism.
    • Alpha-tocopherol was identified as the predominant tocopherol fraction across all measured components.

    Conclusions:

    • Human platelets possess a unique mechanism for accumulating high levels of tocopherol, independent of polyunsaturated fatty acid content.
    • Platelets appear to have limited capacity for exogenous tocopherol uptake compared to erythrocytes and plasma.
    • Tocopherol supplementation effectively increases vitamin E levels in plasma and erythrocytes, but not in circulating platelets.
    • These findings highlight differential tocopherol dynamics within blood components and suggest specific strategies for targeting vitamin E delivery.