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Updated: Jul 30, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 3, 2015
[Structural and functional changes in various cells following radiation exposure]
A V Paranich1, K V Tyslenko, N A Frolova
1Karazin Khar'kov National University, Khar'kov, Ukraine.
Abstract:
Structural and functional changes in thymocytes, splenocytes and hepatocytes, taking place under gamma-irradiation of cellular suspensions were investigated. It was found that splenocytes begin to lose their functional activity and structural features at a dose of 2 Gy. Increasing the irradiation dose leads to the acceleration of these processes. Thymocytes lose rapidly their functional activity at 2 Gy, but they maintain their structure and membrane parameters even after irradiation with a dose of 10 Gy. In comparison with other cell types, hepatocytes exhibit the greatest stability under the influence of gamma-radiation.
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