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Updated: Feb 16, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Synthesis and characterization of a disulfide-linked c(5)-symmetric [5]carceplex
Christoph Naumann1, Samuel Place, John C Sherman
1Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Abstract:
The synthesis and characterization of the first disulfide-linked and C5-symmetric carceplex.(guests)2 using the recently described [5]cavitands as building blocks is reported. The solution behavior of the new carceplexes was explored by 1D NOSEY (EXSY) experiments. The disulfides have unusually high energy barriers to interconversion due to their cooperativity. The guests (2 DMF or 2 DMA) reside in an unusual orientation in parallel planes that are perpendicular to the principal axis of the host.
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