Related Experiment Video
Updated: Jul 22, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
Abstract:
Leptin, is a 16 kDa protein derived mainly, though not entirely, from white fat cells. It regulates the size of the body's fat load (i.e., energy reserves) and has a growing list of other functions. The latest addition is bone growth. The evidence so far indicates that leptin controls bone growth in two ways. It stimulates the release of an undefined hypothalamic osteoblast-inhibiting factor(s), which limits the amount of bone matrix that osteoblasts can make. Interestingly, it is itself a bone anabolic factor that directly stimulates bone growth by inducing osteoblasts to make IGF-I (insulin-like growth factor-I) and inhibiting osteoclast generation.
More Related Videos
09:29Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation
Published on: August 4, 2023
06:16White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
Published on: September 9, 2025
Related Concept Videos
Bone Cells and Tissue
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Compact Bone
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Blood and Nerve Supply to the Bones
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...