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Device-directed therapeutic drug delivery systems.

Takehisa Matsuda1

  • 1Department of Biomedical Engineering, Graduate School of Medicine, Kyushu University 3-1-1 Maidashi, Higashiku, 812-8582, Fukuoka, Japan. matsuda@med.kyushu-u.ac.jp

Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 5, 2002
PubMed
Summary

New medical devices and biomaterials enhance drug delivery for cardiovascular and cancerous tissues. These innovations include specialized catheters, stents, and hydrogels for improved therapeutic outcomes.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology
  • Cardiovascular Medicine

Background:

  • Current device-directed drug delivery systems face limitations in therapeutic effectiveness for cardiovascular and cancerous tissues.
  • There is a need for advanced devices and functional biomaterials to overcome these limitations.

Purpose of the Study:

  • To develop novel devices and functional biomaterials for enhanced drug delivery.
  • To explore new therapeutic strategies utilizing these advanced delivery systems.

Main Methods:

  • Development of a drug-infusible balloon catheter.
  • Creation of drug-releasable and covered stents.
  • Implementation of in situ hydrogelation for localized drug delivery in cancerous tissues.

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Main Results:

  • The devised devices and biomaterials are designed to meet specific requirements for targeted drug delivery.
  • New therapeutic strategies leveraging these innovations were discussed, focusing on improved efficacy.

Conclusions:

  • The developed drug delivery systems and strategies show promise for increasing therapeutic effectiveness.
  • These advancements offer potential for improved treatment of cardiovascular diseases and cancers.