Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 12, 2026

Elastomeric PGS Scaffolds in Arterial Tissue Engineering
08:35

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

[Development of elastameric sealant designed for arterial field].

Takehisa Matsuda1, Nobuyuki Nakajima

  • 1Genome Biotechnology Laboratory, Kanazawa Institute of Technology, Hakusan, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery
|April 12, 2013
PubMed
Summary

A new urethane-based surgical sealant effectively stops arterial bleeding within minutes. Tested on canine arteries, this innovative sealant shows no detrimental effects and is nearing market availability.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical Outcomes in Large Vestibular Schwannomas: Proposed Koos Grade V and Radiological Risk Features.

Operative neurosurgery (Hagerstown, Md.)·2026
Same author

Development of ultrasonography for the detection of prostate cancer.

Journal of medical ultrasonics (2001)·2026
Same author

Photodynamic therapy using talaporfin sodium for grade 2/3 meningiomas: a preliminary study of safety, feasibility, and clinical outcomes.

Journal of neuro-oncology·2026
Same author

Management of High Jugular Bulb in Retrosigmoid Surgery for Vestibular Schwannoma: Analysis of 590 Consecutive Cases.

Operative neurosurgery (Hagerstown, Md.)·2026
Same author

Surgical Concept and Long-Term Outcomes of Various Case-by-Case Decompressive Techniques for Trigeminal Neuralgia Caused by the Trigeminocerebellar Artery.

Operative neurosurgery (Hagerstown, Md.)·2025
Same author

Robot-assisted radical nephrectomy in comparison with open and laparoscopic approaches: a Japanese single-institution retrospective study.

Journal of robotic surgery·2025

Area of Science:

  • Biomaterials science
  • Vascular surgery
  • Polymer chemistry

Context:

  • Arterial dissection and repair present challenges for hemostasis due to pulsatile blood flow.
  • Existing surgical sealants often lack specificity or efficacy for delicate arterial tissues.
  • The development of a reliable arterial tissue sealant is a significant unmet need in cardiovascular surgery.

Purpose:

  • To propose an ideal adhesion mechanism for surgical sealants based on biomechanical principles.
  • To develop and evaluate a novel urethane prepolymer-based sealant for arterial hemostasis.
  • To assess the sealant's efficacy and biocompatibility in a canine arterial model.

Summary:

  • A urethane prepolymer sealant was designed based on biomechanical adhesion principles for arterial hemostasis.

More Related Videos

Applying Permanent, Robust Stenciled Patterns of Fine Particles to Elastomeric Surfaces
07:12

Applying Permanent, Robust Stenciled Patterns of Fine Particles to Elastomeric Surfaces

Published on: July 8, 2025

Accessible Silicone Chip-to-Membrane Sealing Procedure for Flexible, Reliable Bonding
06:10

Accessible Silicone Chip-to-Membrane Sealing Procedure for Flexible, Reliable Bonding

Published on: March 20, 2026

Related Experiment Videos

Last Updated: May 12, 2026

Elastomeric PGS Scaffolds in Arterial Tissue Engineering
08:35

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

Applying Permanent, Robust Stenciled Patterns of Fine Particles to Elastomeric Surfaces
07:12

Applying Permanent, Robust Stenciled Patterns of Fine Particles to Elastomeric Surfaces

Published on: July 8, 2025

Accessible Silicone Chip-to-Membrane Sealing Procedure for Flexible, Reliable Bonding
06:10

Accessible Silicone Chip-to-Membrane Sealing Procedure for Flexible, Reliable Bonding

Published on: March 20, 2026

  • The sealant exhibits high water absorbency and rapid curing to an elastomer within minutes upon application to vascular tissue.
  • In canine abdominal artery models, the sealant achieved hemostasis within 5 minutes post-application without adverse effects on tissue or morphogenesis.

    • Impact:

    • This novel sealant offers a promising solution for achieving reliable hemostasis in arterial dissections.
    • Successful preclinical evaluation suggests potential for improved patient outcomes in vascular and cardiovascular procedures.
    • The sealant's rapid action and biocompatibility pave the way for its clinical adoption and market release.