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Preclinical trials of human erythrocyte superoxide dismutase injection
1Institute of Applied Free Radical Biology and Medicine, Chengdu Military District, Chengdu 610214, China.
Objective:
To assess the quality of human erythrocyte superoxide dismutase (SOD) injection reaching the official standard for its clinical uses.
Methods:
Human erythrocyte SOD injection prepared by McCord-Fridovich's method without column chromatography but with some modifications was used in preclinical trials, to observe the general pharmacology and pharmacodynamics of the product.
Results:
The quality of human erythrocyte SOD injection conformed to the official standard of a biological product, which was found to be non-toxic and did not have any effects on the central and autonomic nervous systems as well as cardiovascular and respiratory systems. The efficacy of anti-inflammation and promotion of immuno-regulation especially on carrageenan and adjuvant-induced polyarthritis were shown in animals.
Conclusion:
Human erythrocyte SOD injection is appropriate for prophylactic and therapeutic uses in clinical trials.
