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New biotransformation products of nemadectins
K Fang1, G Schlingmann, A Enos
1Wyeth-Ayerst Research, Natural Products Chemistry, Pearl River, NY 10965, USA.
The Journal of Antibiotics
|January 5, 2002
Abstract:
Selected nemadectins (formerly LL-F28249 series) have been fed to a panel of microorganisms with the aim of generating new derivatives. In addition to products resulting from the oxidation of the terminal methyl group (C-29), a unique phosphorylated nemadectin was isolated. The phosphate group was determined to be at C-23 by HMBC between phosphorus and H-23. Milbemycin or nemadectin derivatives with natural substituents involving the 23-hydroxyl group were hitherto unknown.