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[Transcatheter arterial chemoembolization combined with external radiation for primary liver cancer]
Objective:
To evaluate the therapeutic efficacy of transcatheter arterial chemoembolization (TACE) combined with external radiotherapy (RT) for primary liver cancer.
Methods:
The effectiveness of combined therapy with TACE and RT (76 cases) and TACE therapy alone (68 cases) was prospectively nonrandomly studied.
Results:
In TACE + RT group, the response rate (CR + PR) was 53.9%, and the 1-, 2-, 3-year survival rate was 71.6%, 49.0%, and 44.5%, respectively. In contrast, the response rate of TACE alone was 33.8%, and the 1-, 2-, 3-year survival rate was 51.8%, 17.3%, and 17.3%, respectively. The difference between these two groups was statistically significant (P < 0.05). Factors of prognostic significance in the TACE + RT group were tumor type, tumor cell thrombi in the portal system, number of TACE treatment and the use of gelform in embolization.
Conclusion:
TACE + RT is more effective than TACE therapy alone. Understanding of the prognostic factors is useful for selection and management of patients.