[Dendritic cell infiltration in lung adenocarcinoma and its effect on prognosis]
1Department of Pathology, Cancer Hospital of Hubei Province, Wuhan 430070, China.
Objective:
To study the infiltration degree of dendritic cells in lung adenocarcinoma and its effect on prognosis.
Methods:
S-100 protein was used as the specific marker for dendritic cells, and immunohistochemistry was employed to detect the distribution of dendritic cells in lung adenocarcinoma.
Results:
Among 46 cases of lung adenocarcinoma, 19 were markedly infiltrated by dendritic cells, the five-year survival rate being 61%; 27 showed slight infiltration, the five-year survival rate being 21%. Among the 46 cases of adenocarcinoma, 26 were low differentiated adenocarcinoma, in which 10 were infiltrated markedly by dendritic cells, five-year survival rate being 57%; and 16 were slightly infiltrated, five-year survival rate being 16%. These data were evaluated with the log-rank test, which showed a significant difference between the markedly infiltrated group and the slightly infiltrated group.
Conclusion:
The prognosis of lung adenocarcinoma which markedly infiltrated by dendritic cells is better than that of slightly infiltrated by dendritic cells.
