Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging-related changes in the multifocal electroretinogram.

Gregory R Jackson1, JulioDeLeon Ortega, Christopher Girkin

  • 1Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, 35294-0009, USA. jackson@eyes.uab.edu

Journal of the Optical Society of America. A, Optics, Image Science, and Vision
|January 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impaired Rod-Mediated Vision is the Functional Hallmark of Ageing and Early and Intermediate Age-Related Macular Degeneration.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)·2026
Same author

A Manual of Procedures for the Generation of the AI-Ready and Exploratory Atlas for Diabetes Insights (AI-READI) Database.

medRxiv : the preprint server for health sciences·2026
Same author

A Comparative Analysis of Visual Field Test Results Using Tablet-Based and Table-Mounted Devices in a Telemedicine Program Set in Underserved Areas.

Translational vision science & technology·2026
Same author

Choriocapillaris Flow Signal Deficits Are Associated With AMD Onset and Early Progression Over Three Years: ALSTAR2 Follow-Up.

Investigative ophthalmology & visual science·2026
Same author

The Science of Rod-Mediated Dark Adaptation, an Outcome Measure for Age-Related Macular Degeneration: The 2025 Proctor Medal Lecture.

Investigative ophthalmology & visual science·2026
Same author

Standardizing Measurement of Complete Retinal Pigment Epithelial and Outer Retinal Atrophy: Classification of Atrophy Meeting Report 8.

Ophthalmology. Retina·2026
Same journal

Multi-module collaborative optimization-driven fast speckle correlation imaging in variable environments.

Journal of the Optical Society of America. A, Optics, image science, and vision·2026
Same journal

Secrecy performance analysis of NOMA-UWOC systems over a vertically stratified WGG oceanic turbulence channel.

Journal of the Optical Society of America. A, Optics, image science, and vision·2026
Same journal

Backscattering of plane waves in a composite system containing a rough surface and anisotropic scatterers.

Journal of the Optical Society of America. A, Optics, image science, and vision·2026
Same journal

Aspherical surface construction methods based on extended Jacobi polynomials.

Journal of the Optical Society of America. A, Optics, image science, and vision·2026
Same journal

OCT sidelobe suppression method based on dual-path phase sinusoidal modulation and minimum value fusion.

Journal of the Optical Society of America. A, Optics, image science, and vision·2026
Same journal

Optical design concepts using wavelength-selective diffractive optics to enable miniaturized multimodal endoscopic imaging across separated spectral ranges.

Journal of the Optical Society of America. A, Optics, image science, and vision·2026
See all related articles

Older adults show reduced retinal function, as measured by multifocal electroretinogram (MERG). This age-related decline in MERG responses, particularly in the fovea, may stem from slower retinal adaptation.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Gerontology

Background:

  • The aging process can affect retinal function, impacting visual perception.
  • The multifocal electroretinogram (MERG) is a valuable tool for assessing localized retinal function.

Purpose of the Study:

  • To investigate age-related changes in retinal function using MERG.
  • To compare MERG responses between young and old adults with healthy retinas.

Main Methods:

  • Recorded multifocal electroretinograms (MERG) in the central 36-degree field of 26 young (19-30 years) and 20 old (60-74 years) adults.
  • Assessed retinal health using a fundus grading scale.
  • Analyzed amplitude densities and waveform peaks of MERG responses.

Main Results:

Related Experiment Videos

  • Older adults exhibited lower mean amplitude densities for first- and second-order MERG responses compared to young adults.
  • The reduction in first-order amplitude density was most pronounced at the fovea and decreased with eccentricity.
  • Both negative and positive peak amplitudes of the first-order MERG waveform were reduced with age, showing a similar eccentricity-dependent pattern.

Conclusions:

  • Aging is associated with a decline in retinal function, evidenced by reduced MERG responses.
  • The observed age-related changes in MERG may be attributed to slowed temporal adaptation in the retina.
  • MERG can detect functional differences in the aging retina, with greater impact in central areas like the fovea.