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Related Experiment Videos

High-throughput structural proteomics using x-rays.

H Jhoti1

  • 1Astex Technology, Cambridge, UK. h.jhoti@astex-technology.com

Trends in Biotechnology
|January 10, 2002
PubMed
Summary
This summary is machine-generated.

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Biochemistry·1998

The human genome

Area of Science:

  • Structural biology
  • Genomics
  • Drug discovery

Background:

  • The completion of the human genome sequence has shifted research focus from DNA to proteins.
  • Understanding protein function is crucial for biological research and medicine.

Purpose of the Study:

  • To highlight the importance of protein structure determination.
  • To emphasize the role of X-ray crystallography in advancing functional analysis and drug design.

Main Methods:

  • X-ray crystallography for protein structure determination.
  • High-throughput structure determination techniques.

Main Results:

  • Rapid determination of novel protein crystal structures is now feasible.
  • Accelerated functional analysis of newly identified proteins.

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Conclusions:

  • Advances in X-ray crystallography are key to understanding protein function post-genomic era.
  • This facilitates rational drug design and development programs.