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The evolution of the MHC-G gene does not support a functional role for the complete protein
A Arnaiz-Villena1, J Martinez-Laso, M J Castro
1Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain. aarnaiz@eucmax.sim.ucm.es
Immunological Reviews
|January 10, 2002
Abstract:
The study of the MHC-G gene evolution during nearly 40 million years does not support a role for the full molecule. The MHC-G-like proteins of New World monkeys are probably classical presenting molecules. Old World Cercopithecinae monkeys do not have a full MHC-G molecule and human individuals homozygous for the HLA-G null allele are healthy and do not show birth pathologies.