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Related Experiment Videos

Meperidine: a critical review.

Kenneth S Latta1, Brian Ginsberg, Robert L Barkin

  • 1Department of Pharmacy, Duke University Medical Center, Durham, North Carolina 27710, USA. latta001@mc.duke.edu

American Journal of Therapeutics
|January 10, 2002
PubMed
Summary
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Meperidine (Demerol) is not a superior analgesic for biliary or renal spasms compared to other opioids. Its use is limited by poor efficacy, significant toxicity, and drug interactions, prompting a shift towards safer alternatives.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Drug Efficacy Studies

Background:

  • Meperidine (Demerol) was initially developed as an anticholinergic agent.
  • Its analgesic properties were discovered, leading to its use in pain management.
  • Despite in vivo evidence of anticholinergic effects, specific actions on biliary and renal tracts remained unproven in vivo.

Purpose of the Study:

  • To evaluate the efficacy of meperidine in treating biliary and renal tract spasms.
  • To compare meperidine's effectiveness against other mu-opioid analgesics.
  • To review the evidence supporting meperidine's purported unique clinical advantages.

Main Methods:

  • Review of existing studies, including case reports and comparative trials.
  • Analysis of clinical data regarding meperidine's efficacy and side effect profile.

Related Experiment Videos

  • Comparison of meperidine with other opioid analgesics in managing specific types of pain.

    • Main Results:

    • Studies indicate meperidine offers no superior efficacy for biliary or renal tract spasm compared to other mu-opioids.
    • Initial evidence for meperidine's analgesic efficacy was largely based on non-randomized case reports.
    • Comparative studies failed to demonstrate advantages of meperidine over equivalent doses of other analgesics.
    • Meperidine is associated with unique toxicities, including serotonergic crisis and normeperidine toxicity.

    Conclusions:

    • Meperidine exhibits limited analgesic efficacy and significant toxicity.
    • Its use is complicated by adverse effects and drug interactions.
    • There is a clinical trend to substitute meperidine with more effective and safer opioid analgesics.