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[A study on cyclooxygenase-2 protein expression in esophageal carcinoma and premalignant lesions]
1Department of Pathology, First Hospital of Harbin Medical University, Harbin 150001, China.
Objective:
To investigate cyclooxygenase-2(Cox-2) protein expression in esophageal cancer and precancerous lesions.
Methods:
One hundred twenty biopsy specimens from patients with esophageal carcinoma, 113 from patients with esophageal premalignant lesions, 27 from individuals with normal esophageal mucosa and 3 from Barrett's esophagus were examined for Cox-2 protein expression by immunohistochemistry.
Results:
Cox-2 protein was not observed in normal esophageal squamous and glandular epithelium, hyperplasia from mild to severe dysplasia lesions and carcinoma in situ. Positive Cox-2 expression was found in 4 of 60 specimens of invasive squamous-cell carcinomas, 21 of 30 specimens of esophageal adenocarcinomas and in 3 of 3 Barrett's esophageal tissues.
Conclusion:
The Cox-2 protein expression may be associated with the development of the esophageal adenocarcinomas but not esophageal squamous-cell carcinomas.