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[Expression of VEGF, bFGF and ER in endometrial carcinoma]
1Gynecology and Obstetrics Department, General Hospital of Tianjin Medical University, Tianjin 300052, China.
Objective:
To investigate the expression of VEGF, bFGF and ER in endometrial carcinoma and its relation to the clinico-pathological manifestations and prognosis.
Methods:
A total of 66 specimens of endometrial carcinoma and 19 normal endometrium was studied by immunohistological technique with polyclonal antibodies against VEGF and bFGF, and monoclonal antibody against ER.
Results:
Positive expression rate of VEGF in endometrial carcinoma was 80.3%. Expression of VEGF was positively correlated with tumor grade (P < 0.01). Expression of VEGF was positively correlated with that of bFGF (P < 0.05). Negative correlation was observed between ER expression and tumor grade (P < 0.05). Prognosis of patients with negative ER expression was poor. No correlation existed between ER expression and that of VEGF and bFGF.
Conclusion:
Expression of VEGF and bFGF may indicate that both of them contribute in the angiogenesis of endometrial carcinoma. Expression of ER has prognostic significance.