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[Improvement and application of multi-infarct dementia model in rats]
Abstract
Objective:
To improve the method of inducing the multi-infarct dementia (MID) model in rats to observe the pharmacodynamic effect of Jiannao Yizhi (JNYZ) granule on MID.
Methods:
Retrograde injection with the homologous embolus through the external carotid artery initiated the multi-infarct dementia in rats. The experiment of behavior and morphology were conducted.
Results:
The extensive and multiple foci of infarction and the obviously declining ability of learning and memory were observed in the model group; the action of JNYZ granule and hydergine could obviously improve them.
Conclusion:
This model is useful to carry out basic research and screen new drugs in treating MID.