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[Cardiac protective effects of tetramethylpyrazine in patients performed open-heart operation with cardiopulmonary
1Department of Cardiovascular Surgery, Union Hospital, Tongji Medical University, Wuhan (430022).
Objective:
To study the cardiac protective effects of tetramethylpyrazine (TMP) on patients undergoing cardiac operation.
Methods:
Twelve patients with rheumatic heart disease were randomly divided into the TMP group and the control group, 6 in each group. The changes of hemodynamics, serum creatine phosphokinase (CPK), creatine phosphokinase isoenzyme (CPK-MB) levels were observed before, during and 72 hours after operation.
Results:
The hemodynamic indexes in the TMP group were better than those in the control group after operation, the serum CPK, CPK-MB levels measuring 12 h, 24 h and 48 h after operation in the TMP group were lower than those in the control group.
Conclusion:
TMP has good cardiac protective function in patients undergoing cardiac operation in improving cardial function and reducing the release of myocardial enzymes.
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