Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple pathways governing Cdx1 expression during murine development.

P Prinos1, S Joseph, K Oh

  • 1Institut de Recherches Cliniques de Montréal, 110 ave des Pins, ouest, Montréal, Québec, Canada H2W 1R7.

Developmental Biology
|January 11, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics, management and outcome of a large necrotising otitis externa case series: need for standardised case definition.

The Journal of laryngology and otology·2022
Same author

Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run.

Physical review letters·2021
Same author

Polarization of Λ (Λ[over ¯]) Hyperons along the Beam Direction in Au+Au Collisions at sqrt[s_{NN}]=200  GeV.

Physical review letters·2019
Same author

Observation of Excess J/ψ Yield at Very Low Transverse Momenta in Au+Au Collisions at sqrt[s_{NN}]=200  GeV and U+U Collisions at sqrt[s_{NN}]=193  GeV.

Physical review letters·2019
Same author

Azimuthal Harmonics in Small and Large Collision Systems at RHIC Top Energies.

Physical review letters·2019
Same author

Erratum: Observation of D^{0} Meson Nuclear Modifications in Au+Au Collisions at sqrt[s_{NN}]=200  GeV [Phys. Rev. Lett. 113, 142301 (2014)].

Physical review letters·2018
Same journal

The Drosophila ovarian terminal filament imports lipophilic molecules that support cyst and follicle development within the ovariole.

Developmental biology·2026
Same journal

Secreted Frizzled-Related Protein 1 Controls Distal Lung Formation via Wnt and PDGF Signaling.

Developmental biology·2026
Same journal

The vascular-osteogenic interface in craniofacial development: a structured review of emerging associations in congenital malformations.

Developmental biology·2026
Same journal

Turning off metamorphosis: Thyroid hormone deregulation in the evolution of obligately paedomorphic salamanders.

Developmental biology·2026
Same journal

Developmental analysis of the cone photoreceptor-less little skate retina reveals distinct Onecut1 isoforms.

Developmental biology·2026
Same journal

Germline cysts require Ecdysone receptor for proper timing of encapsulation in the Drosophila ovary.

Developmental biology·2026
See all related articles

Retinoic acid (RA) and Wnt signaling synergistically initiate Cdx1 expression during embryonic development. Cdx1 then maintains its own expression through an autoregulatory mechanism in later stages.

Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • Cdx1 is a homeobox gene crucial for vertebral patterning.
  • Retinoic acid (RA) plays a role in vertebral development.
  • Cdx1 is a direct retinoid target gene, but RA only affects early expression.

Purpose of the Study:

  • Investigate factors maintaining later stages of Cdx1 expression.
  • Explore the role of Wnt signaling, specifically Wnt3a, in Cdx1 regulation.
  • Elucidate the synergistic effects of Wnt3a and RA on Cdx1 expression.

Main Methods:

  • Analysis of Cdx1 expression in Wnt3a hypomorph (vestigial tail).
  • Identification of LEF/TCF response motifs for Wnt regulation.
  • Experimental validation of Wnt3a and RA synergy on Cdx1 activation.

Related Experiment Videos

Main Results:

  • Wnt signaling directly regulates Cdx1 expression via LEF/TCF motifs.
  • Cdx1 expression is reduced in Wnt3a hypomorph.
  • Wnt3a and RA synergistically activate Cdx1 expression.
  • Cdx1 positively regulates its own expression.

Conclusions:

  • Retinoid and Wnt signaling synergistically initiate Cdx1 expression in the caudal embryo.
  • Cdx1 autoregulation contributes to maintaining its expression at later stages.
  • This provides a model for Cdx1 regulation during vertebral development.