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Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Tandem chain extension-aldol reaction: syn selectivity with a zinc enolate

S Lai1, C K Zercher, J P Jasinski

  • 1Department of Chemistry, University of New Hampshire, Durham, NH 03824, USA.

Organic Letters
|January 11, 2002
PubMed
Summary

A novel zinc-mediated reaction efficiently converts beta-keto esters into valuable alpha-substituted-gamma-keto esters in a single step. This tandem chain extension-aldol process offers excellent control over stereochemistry for various substrates.

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