Therapy with proteolytic enzymes in rheumatic disorders

Area of Science:

• Pharmacology
• Rheumatology
• Biochemistry

Background:

• Proteolytic enzymes from plants and pancreas are used in traditional and modern medicine.
• Empirical use of enzyme therapy in rheumatic disorders is supported by scientific evidence.

Purpose of the Study:

• To review preclinical and clinical trials of systemic enzyme therapy for rheumatic disorders.
• To explore the potential mechanisms and efficacy of oral proteolytic enzyme administration.

Main Methods:

• Review of studies on enzyme preparations (bromelain, papain, trypsin, chymotrypsin) in rheumatic conditions.
• Analysis of preclinical and clinical trial data, including placebo-controlled and comparative studies.

Main Results:

• Oral proteolytic enzymes may influence proteinase-antiproteinase balance and cytokine profiles.
• Studies suggest potential analgesic and anti-inflammatory effects, but results are inconsistent.
• Immunomodulatory effects indicate possible therapeutic efficacy.

Conclusions:

• Systemic enzyme therapy for rheumatic disorders shows plausible application in carefully selected patients.
• Further research is needed to elucidate precise mechanisms and standardize treatment protocols.