[Effect of Ethrel on the ultrastructure of some internal organs in rats. I. Liver]

Experiments were carried out on white rats. Water solutions of Ethrel (AmChem 68-240) at 10, 100 and 200 mg per kg of body weight were used during seven days. Enlargement of Disse's space, as well as the appearance of many fibrous elements were observed in the liver. The number of the lipid droplets increased in the cytoplasm of the hepatocytes, and some of the mitochondria were swollen. An increase of the level of aminotranspherases (AlAT and AspAT) was stated in the blood of the animals. The changes described above had a reversible character; a disturbance of the intracellular metabolism and of the action of the liver cells can be stated rather than toxic injuries to the liver.