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Endovascular brachytherapy in the prevention of vascular restenosis
J Dvorák1, J Fridrich, J Raupach
1Department of Radiotherapy and Oncology, Charles University Hospital, Hradec Králové, Czech Republic. dvorakj@fnhk.cz
Purpose:
To evaluate the technical feasibility and efficacy of endovascular brachytherapy for prophylaxis of restenosis after femoropopliteal percutaneous transluminal angioplasty (PTA).
Materials And Methods:
Ten patients with recurrence of stenosis in the femoropopliteal region underwent PTA followed by endovascular irradiation with Iridium-192 a high-dose rate after-loading technique. We used a single fraction of dose 12 Gy given in 3 mm from the source axis in the stenotic vessel segment.
Results:
During follow-up of 59-580 days restenosis occurred in four patients 111, 460, 472 and 580 days after irradiation. All other patients are without restenosis. No radiation-associated side effects were observed.
Conclusions:
Endovascular brachytherapy of restenosis in the femoropopliteal region is technically feasible, and may be done as a part of the PTA. These encouraging results open the possibility of reduction of restenosis by the present method.