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Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
Published on: March 28, 2013
Peroxisome proliferator-activated receptor gamma and atherosclerosis
1Department of Internal Medicine II-Cardiology, University of Ulm, Robert-Koch-Str. 8, D-89081 Ulm, Germany. nikolaus.marx@medizin.uni-ulm.de
Abstract:
Within the past couple of years, peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear transcription factor expressed in vascular cells, has received growing interest in vascular biology and atherosclerosis research. Initially, PPARgamma was identified as a regulator of gene expression in lipid metabolism and adipogenesis, but recent data in monocyte/macrophages, endothelial cells, and vascular smooth muscle cells suggest that PPARgamma might have anti-inflammatory effects in atherogenesis. However, with growing insight, there is much controversy about potential anti- or proatherosclerotic effects. This review will focus on these aspects and discuss what PPARgamma activation in vascular cells could mean for atherogenesis and the development of atherosclerosis.
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