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Related Experiment Videos

Alginate/chitosan particulate systems for sodium diclofenac release.

M L González-Rodríguez1, M A Holgado, C Sánchez-Lafuente

  • 1Departamento de Farmacia y Tecnología Farmacacéutica, Facultad de Farmacia, C/Profesor Garcia Gonzalez s/n, Universidad de Sevilla, 41012, Sevilla, Spain. rabasco@fafar.us.es

International Journal of Pharmaceutics
|January 16, 2002
PubMed
Summary

Alginate/chitosan particles control sodium diclofenac release, with release inhibited at acidic pH but rapid at pH 6.4-7.2. Particle composition and cation type modulate drug release rates.

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Area of Science:

  • Materials Science
  • Drug Delivery Systems
  • Biomaterials

Background:

  • Alginate and chitosan are biocompatible polymers frequently used in drug delivery.
  • Controlling the release rate of active pharmaceutical ingredients is crucial for effective drug therapy.
  • Ionic gelation is a common method for forming polymer particles for encapsulation.

Purpose of the Study:

  • To prepare and characterize alginate/chitosan particles for sodium diclofenac release.
  • To investigate the influence of pH and technological parameters on drug release kinetics.
  • To explore the role of the alginate/chitosan ratio and gelifying cation on release modulation.

Main Methods:

  • Preparation of alginate/chitosan particles via ionic gelation using Ca2+ and Al3+.

Related Experiment Videos

  • Characterization using electron microscopy and differential scanning calorimetry.
  • In vitro drug release studies at varying pH levels and analysis of influencing factors.

    • Main Results:

    • Sodium diclofenac release was completely inhibited at acidic pH.
    • Rapid and complete drug release was observed within minutes at pH 6.4 and 7.2.
    • The alginate/chitosan ratio and the choice of gelifying cation (Ca2+ vs. Al3+) significantly controlled the release rate.

    Conclusions:

    • Alginate/chitosan particles offer tunable properties for controlled sodium diclofenac release.
    • The pH of the dissolution medium is a critical factor determining drug release.
    • This system demonstrates potential for developing effective drug delivery formulations.