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Work-up strategies for high-throughput solution synthesis.
1Takeda Chemical Industries, Medicinal Chemistry Research, Laboratories I, Pharmaceutical Research Division 17-85 Juso-Honmachi 2-ChomeYodogawa-Ku, Osaka, 532-8686, Japan.
Drug Discovery Today
|January 16, 2002
Summary
The main challenge in parallel synthesis is product isolation and purification. Recent advances in solution-phase chemistry offer efficient high-throughput work-up tools for medicinal chemistry.
Area of Science:
- Synthetic Chemistry
- Medicinal Chemistry
Background:
- The primary limitation in parallel synthesis has historically been the isolation and purification of reaction products.
- The execution of the reactions themselves is generally not the bottleneck.
Purpose of the Study:
- To highlight the re-emphasis on solution-phase chemistry for parallel synthesis.
- To discuss the development and acceptance of new tools for high-throughput work-up.
Main Methods:
- Focus on solution-phase chemistry techniques.
- Development of practical tools for efficient work-up procedures.
Main Results:
- Stimulation of a wide range of practical tools for high-throughput work-up.
- Increasing acceptance of these tools within medicinal chemistry groups.
Conclusions:
- Efficient product isolation and purification are critical for parallel synthesis.
- Advancements in solution-phase chemistry are providing effective solutions for high-throughput work-up in medicinal chemistry.