Work-up strategies for high-throughput solution synthesis
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Updated: Oct 3, 2026

Discovery and Synthesis Optimization of Isoreticular Al(III) Phosphonate-Based Metal-Organic Framework Compounds Using High-Throughput Methods
Published on: October 6, 2023
1Takeda Chemical Industries, Medicinal Chemistry Research, Laboratories I, Pharmaceutical Research Division 17-85 Juso-Honmachi 2-ChomeYodogawa-Ku, Osaka, 532-8686, Japan.
Abstract:
The key bottleneck in parallel synthesis has, in truth, always been the isolation and purification of the reaction products, rather than carrying out the reactions themselves. Solution-phase chemistry for parallel synthesis has recently been re-emphasized and has stimulated the development of a wide-range of practical tools for efficient high-throughput work-up, which are gaining increasing acceptance in medicinal chemistry groups.

