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Angiotensin II regulates oxygen consumption
Lisa Cassis1, Marc Helton, Vicki English
1Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0082, USA. lcassis@pop.uky.edu
Summary
Angiotensin II (ANG II) reduces body weight by decreasing food intake and transiently lowering energy expenditure. Chronic exposure suggests a role for energy expenditure in sustained weight loss.
Area of Science:
- Physiology
- Endocrinology
- Metabolism
Background:
- Previous research indicates that angiotensin II (ANG II) administration leads to decreased body weight.
- The precise mechanisms by which ANG II influences body weight remain incompletely understood.
Purpose of the Study:
- To investigate whether angiotensin II regulates body weight through modulation of energy expenditure.
- To elucidate the temporal relationship between ANG II, energy intake, and energy expenditure.
Main Methods:
- Rats were infused with angiotensin II (ANG II) or saline for 14 and 28 days.
- Measurements included oxygen consumption, body weight, food intake, systolic blood pressure, and water intake.
- Pair-feeding studies and coadministration of the ANG II receptor blocker losartan were employed.
Main Results:
- Acute ANG II administration transiently decreased oxygen consumption.
- Chronic ANG II infusion for 14 days reduced body weight and food intake, with food intake accounting for 63% of the weight loss.
- Losartan blocked ANG II's effects on body weight, food intake, blood pressure, and water intake, but only partially prevented reductions in oxygen consumption.
Conclusions:
- Angiotensin II transiently reduces oxygen consumption via mechanisms independent of food intake.
- Chronic ANG II exposure may involve energy expenditure in sustained body weight reduction.