Related Experiment Video
Updated: Aug 14, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
The effect of genotype and pedigree error on linkage analysis: analysis of three asthma genome scans
S S Cherny1, G R Abecasis, W O Cookson
1Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Abstract:
The effects of genotype and relationship errors on linkage results are evaluated in three of the Genetic Analysis Workshop 12 asthma genome scans. A number of errors are detected in the samples. While the evidence for linkage is not striking in any data set with or without error, in some cases the difference in test statistic could support different conclusions. The results provide empirical evidence for the predicted effects of genotype and relationship error and highlight the need for rigorous detection and elimination of data error in complex trait studies.
More Related Videos
Related Concept Videos
Dihybrid Crosses
Pedigree Analysis
Pedigree Analysis
Incomplete Dominance
Epistasis Analysis
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...

