Related Experiment Video
Updated: Aug 17, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Inclusion of candidate region studies in meta-analysis using the genome screen meta-analysis method: application to
1Division of Medical and Molecular Genetics, Guy's, King's and St. Thomas' School of Medicine, London, United Kingdom.
Abstract:
An extension to the genome screen meta-analysis (GSMA) method is proposed that allows results from candidate region studies to be included in a meta-analysis of genome-wide search results. Quantitative linkage analyses for susceptibility loci linked to total IgE were performed for data from three genome-wide searches and four candidate region studies from the Genetic Analysis Workshop 12 asthma data set. The GSMA and proposed extension were used to carry out a meta-analysis of the results from these studies. The meta-analysis indicates strong evidence for a susceptibility locus on the p-arm of chromosome 6 and some evidence for susceptibility loci on chromosomes 2, 9, 10, and 15. There is no evidence from this meta-analysis for a susceptibility locus for total IgE on chromosome 5. A method for assessing the possible effect of publication bias is also introduced.
Related Concept Videos
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
