Exploiting linkage disequilibrium in population isolates
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Updated: Oct 2, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
R Culverhouse1, J Lin, K Y Liu
1Department of Psychiatry, Washington University School of Medicine, Box 8134, Dept. of Psychiatry, 660 South Euclid, St. Louis, MO 63110, USA.
Abstract:
A comparison of haplotype frequencies between unrelated cases and controls from population isolates identifies a strong signal for the presence/absence of the discrete phenotype in an interval on chromosome 6 bounded by markers 34 and 35. We define a dissimilarity index, D, which is sensitive to differences in allele distributions and differences in the patterns of linkage disequilibrium between cases and controls. We describe two statistical methods to utilize D: a method appropriate for a single moderately sized sample and a sequential approach appropriate for multiple small independent samples.
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