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Linkage analysis of Genetic Analysis Workshop 12 simulated data based on affected individuals only
1Dept. of Medical Genetics, Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Addenbrookes Hospital, Cambridge CB2 2XY, UK.
Genetic Epidemiology
|January 17, 2002
Abstract:
A variety of allele-sharing methods was used to assess linkage to disease for a whole-genome screen in each of ten replicates from the Genetic Analysis Workshop 12 simulated data. Analysis of each replicate produced many false positive results in addition to a few "true" positives. Conditioning on the strongest initial linkage and reanalyzing using a variety of conditional methods did not improve the power for detection or help discriminate between true and false positive signals.