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[Anticholinergic syndrome after postoperative dimenhydrinate administration]
F Matschiner1, A Berghaus, A Kober
1Universitätsklinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Strasse 12, 06097 Halle.
HNO
|January 17, 2002
Summary
Anticholinergic syndrome is rarely seen with therapeutic drug doses. A case report details successful physostigmine treatment for dimenhydrinate-induced anticholinergic syndrome after surgery.
Area of Science:
- Pharmacology
- Clinical Toxicology
Background:
- Anticholinergic syndrome is an uncommon adverse drug reaction.
- Dimenhydrinate is frequently prescribed for postoperative nausea and vomiting.
Observation:
- A patient developed anticholinergic syndrome despite receiving dimenhydrinate at therapeutic dosages.
- Symptoms included those characteristic of anticholinergic toxicity.
Findings:
- The case report details the onset and progression of anticholinergic syndrome.
- Physostigmine effectively reversed the observed anticholinergic effects.
Implications:
- This case highlights the potential for anticholinergic syndrome even with standard dimenhydrinate dosing.
- Physostigmine should be considered in managing severe anticholinergic toxicity.
- Clinicians should maintain awareness of anticholinergic side effects with dimenhydrinate use.