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1National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. shermans@nia.nih.gov
Annals of the New York Academy of Sciences
|January 25, 2002
Summary
New selective estrogen receptor modulators (SERMs) show promise for disease prevention and treatment. Further research into estrogen receptor (ER) action and coregulators is crucial for developing optimal SERMs.
Area of Science:
- Endocrinology and Pharmacology
- Molecular Biology
- Drug Development
Background:
- Selective estrogen receptor modulators (SERMs) have advanced significantly.
- New SERMs offer potential for broad-spectrum disease prevention and treatment with improved safety profiles.
Purpose of the Study:
- To explore the potential of novel SERMs in diverse physiological systems.
- To reevaluate the concept of an "ideal" SERM for disease prevention.
- To guide future research in SERM development and application.
Main Methods:
- Investigating estrogen's cellular and molecular effects.
- Examining estrogen receptor (ER) mechanisms and coregulator roles.
- Developing efficient clinical trial designs and outcome measures.
Main Results:
- Emerging SERMs demonstrate potential for improved efficacy and risk/benefit ratios.
- Understanding ER action at the cellular and molecular levels is key.
- Elucidating the role of ER coregulators is a high research priority.
Conclusions:
- Continued research into estrogen action is vital for advancing SERM development.
- Optimizing SERMs requires better understanding of ER mechanisms and coregulators.
- Future SERM advances may impact other nuclear hormone receptor-related pathologies.