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Gene therapy for cardiovascular disorders: is there a future?
B L Metcalfe1, K W Sellers, M J Jeng
1Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville 32610, USA.
Annals of the New York Academy of Sciences
|January 25, 2002
Summary
Cardiovascular disease incidence is rising, prompting exploration of gene therapy as drug treatments plateau. This review covers gene therapy approaches for cardiovascular diseases and future therapeutic technologies.
Area of Science:
- Cardiovascular Medicine
- Molecular Biology
- Biotechnology
Background:
- Cardiovascular disease (CVD) incidence is at epidemic levels globally.
- Current pharmacotherapeutics for CVD show diminishing returns, suggesting a plateau in drug efficacy.
- This necessitates exploring novel therapeutic strategies beyond conventional drug treatments.
Purpose of the Study:
- To review the "proof of principle" for gene therapy in treating cardiovascular diseases.
- To present various gene transfer approaches currently under investigation for CVD.
- To discuss the future trajectory of gene therapy and emerging technologies in cardiovascular therapeutics.
Main Methods:
- Literature review of preclinical and clinical studies on gene therapy for cardiovascular conditions.
- Analysis of different gene transfer vectors and strategies.
- Discussion of challenges and future directions in the field.
Main Results:
- Gene therapy holds promise for long-term control of cardiovascular pathophysiological conditions.
- Multiple gene transfer approaches are being developed and tested.
- Significant progress has been made in establishing the feasibility of gene therapy for CVD.
Conclusions:
- Gene therapy represents a promising frontier for managing cardiovascular diseases.
- Continued research and technological advancements are crucial for realizing the full potential of gene therapy.
- The integration of gene therapy with other emerging technologies may revolutionize cardiovascular medicine.