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Synthesis and application of a chain-terminating dinucleotide mRNA cap analog
Zheng-Hong Peng1, Vivek Sharma, Scott F Singleton
1Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030, USA.
Organic Letters
|February 14, 2002
Abstract:
[structure: see text] We describe the synthesis of a chain-terminating mRNA cap dinucleotide and its use in the in vitro transcription of homogeneously capped RNA. Computer modeling strongly indicates that RNA capped with the new compound will be a substrate for cap-dependent translation.