Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Properties of Enantiomers and Optical Activity02:24

Properties of Enantiomers and Optical Activity

21.0K
It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...
21.0K
Prochirality02:05

Prochirality

4.8K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
4.8K
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

6.8K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
6.8K
Chirality in Nature02:30

Chirality in Nature

16.5K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
16.5K
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons00:58

¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons

3.1K
Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
3.1K
Stereoisomerism02:52

Stereoisomerism

13.8K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
13.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering Chirality in the Solid State: Co-Crystallization as a Strategy for Chiral Induction and Resolution.

Chirality·2026
Same author

Site-selective addition of succinimide motif through nitro-assisted C-H functionalization of (hetero) arenes under rhodium catalysis.

Archives of pharmacal research·2025
Same author

Distinct Selectivity of 2-Aryl Thioquinazolinones in the Sulfur Directing Rh(III)-Catalyzed Amidation Reaction.

The Journal of organic chemistry·2025
Same author

Inorganic-organic hybrids of the phosphotungstate Keggin anion and a Schiff base cation.

Dalton transactions (Cambridge, England : 2003)·2025
Same author

Glassy Adhesion Dynamics Govern Transitions Between Sub-Diffusive and Super-Diffusive Cell Migration on Viscoelastic Substrates.

bioRxiv : the preprint server for biology·2025
Same author

Atrichia with Papular Lesions: Dermoscopy to the Rescue.

Indian journal of dermatology·2025

Related Experiment Video

Updated: Jan 11, 2026

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

8.5K

Chiral Luminescent Sensor for Enantiomer Discrimination.

Vivek Sharma1, Akash Kumar Mishra2, Neeraj Kumar Mishra2

  • 1Department of Chemistry, GLA University, Mathura, India.

Chirality
|November 18, 2025
PubMed
Summary

Chiral fluorescent sensors using nanomaterials like quantum dots and MOFs offer precise enantiomer detection for drugs and biomolecules. Advances focus on hybrid structures for improved sensitivity and real-world applications.

Keywords:
chiral discriminationchiral nanocompositesenantioselective sensingfluorescencemetal–organic frameworksnanosensors

More Related Videos

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation
10:33

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

Published on: February 27, 2019

8.9K
A Micropatterning Assay for Measuring Cell Chirality
08:07

A Micropatterning Assay for Measuring Cell Chirality

Published on: March 11, 2022

2.7K

Related Experiment Videos

Last Updated: Jan 11, 2026

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

8.5K
An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation
10:33

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

Published on: February 27, 2019

8.9K
A Micropatterning Assay for Measuring Cell Chirality
08:07

A Micropatterning Assay for Measuring Cell Chirality

Published on: March 11, 2022

2.7K

Area of Science:

  • Nanomaterials Science
  • Analytical Chemistry
  • Pharmaceutical Sciences

Background:

  • Chiral recognition is crucial for drug safety and efficacy, necessitating selective enantiomer detection.
  • Recent advancements have focused on developing chiral fluorescent sensors with enhanced sensitivity, selectivity, and biocompatibility.

Purpose of the Study:

  • To review the structural design, functionalization, and sensing mechanisms of advanced chiral fluorescent sensors.
  • To highlight the integration of hybrid nanostructures and multifunctional composites for next-generation enantioselective sensing platforms.

Main Methods:

  • Review of recent literature on carbon-based quantum dots (CQDs, CCDs, GQDs), MOFs, and composite nanomaterials for chiral sensing.
  • Analysis of specific examples, including functionalized GQDs, modified QDs, and MOF-based composites.
  • Discussion of sensing mechanisms involving fluorescence, electrochemiluminescence, and coordination chemistry.

Main Results:

  • Development of graphene quantum dots functionalized with D-cysteine for morphine enantiomer discrimination.
  • CdSe/ZnS QDs modified with L-pyroglutamic acid derivatives for stereoselective amino acid detection.
  • Zn-MOC@CQDs and Eu-BTB@D-carnitine MOFs demonstrate enantioselective sensing for lactic acid and enhanced fluorescence recognition.
  • BINOL-derived and carbazole-based sensors achieve high enantioselectivity and ultralow detection limits for amino acids.

Conclusions:

  • Rational design of chiral nanomaterials, particularly hybrid and composite structures, is key to precise enantiomer discrimination.
  • These advanced sensors show significant potential for applications in drug analysis, biosensing, and food quality monitoring.