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Total synthesis of crambescidin 359
Kazuo Nagasawa1, Angelina Georgieva, Hiroyuki Koshino
1Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. nagasawa@iam.u-tokyo.ac.jp
Organic Letters
|February 14, 2002
Abstract:
[structure: see text] Crambescidin 359 (4), which is the "vessel part" of the pentacyclic guanidine alkaloid ptilomycalin A (1), was synthesized for the first time based upon successive 1,3-dipolar cycloaddition reaction. This synthesis established the absolute stereochemistry of 4.