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Published on: March 25, 2016
Unusual morphology in a case of large granular cell leukemia
S Galimberti1, R Riccioni, A Azzarà
1Hematology Division, Department of Oncology, Transplants and Advanced Technologies, University of Pisa, Ospedale S.Chiara, Via Roma 67, 56100 Pisa, Italy.
Abstract:
Large granular lymphocyte proliferative status represents a group of clonal and nonclonal lymphoproliferative disorders of natural killer (NK) or T-cell lineages with common morphological features. Cellular differences may sustain the clinical polymorphism observed in these disorders. Here we report a case of large granular lymphocyte disease unusually expressing CD4+CD8+ clonal T cells and atypical cell morphology in bone marrow.
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