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[Acid phosphatase, ACP (EC 3.1.3.2)].

M Ishibashi1

  • 1Department of Laboratory Medicine, Keio University School of Medicine.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|January 19, 2002
PubMed
Summary

Acid phosphatase (ACP) is a lysosomal enzyme with various tissue-specific isozymes. Prostatic ACP aids in diagnosing prostate disease, while tartrate-resistant ACP (TRACP) serves as a marker for bone and certain leukemia conditions.

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Area of Science:

  • Biochemistry
  • Enzymology
  • Cell Biology

Context:

  • Acid phosphatase (ACP) is a crucial hydrolytic lysosomal enzyme.
  • ACP is produced by various cells and tissues, including the prostate, bone, and liver.
  • Multiple ACP isozymes exhibit distinct tissue specificities.

Purpose:

  • To detail the characteristics and diagnostic relevance of acid phosphatase (ACP) isozymes.
  • To highlight the tissue specificity of ACP isozymes and their electrophoretic separation.
  • To identify specific ACP isozymes and their roles as biomarkers.

Summary:

  • ACP isozymes can be separated into six bands via electrophoresis.
  • Prostatic ACP (bands 2-4) is a key diagnostic marker for prostatic diseases.
  • Tartrate-resistant ACP (TRACP), comprising bands 5a and 5b, has distinct clinical applications. TRACP 5b indicates osteoclast activity, while TRACP 5a is associated with Gaucher's cells and hairy cell leukemia.

Impact:

  • Understanding ACP isozyme function aids in disease diagnosis and monitoring.
  • Electrophoretic analysis of ACP provides valuable insights into cellular and tissue health.
  • TRACP isozymes serve as important diagnostic and prognostic indicators in various hematological and bone-related conditions.

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