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Updated: Jul 30, 2026
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Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
[Analyses of multiple primary lung cancers; recent trend].
M Takao1, F Watanabe, A Shimamoto
1Department of Thoracic Surgery, Mie University School of Medicine, Tsu, Japan.
Kyobu Geka. the Japanese Journal of Thoracic Surgery
|January 19, 2002
Summary
Multiple primary lung cancers (MPLCs) are increasingly detected, especially with high-resolution computed tomography (HRCT). New diagnostic and surgical strategies are needed for these MPLC cases, particularly bronchioloalveolar carcinomas.
Area of Science:
- Oncology
- Thoracic Surgery
- Radiology
Context:
- This study analyzes the incidence and characteristics of multiple primary lung cancers (MPLCs) in patients undergoing surgery.
- Data was collected from 921 patients operated on for primary lung cancer since March 1979 at Mie University Hospital.
Purpose:
- To investigate the trends in MPLC diagnosis, particularly the impact of high-resolution computed tomography (HRCT) introduction.
- To evaluate the clinical presentation and outcomes of MPLC cases, focusing on bronchioloalveolar carcinoma (BAC).
Summary:
- The study identified 14 synchronous and 5 metachronous MPLCs.
- The incidence of synchronous MPLCs significantly increased from 0.7% to 7.5% after HRCT implementation.
- Multiple BACs were often radiographically occult, but amenable to good outcomes with limited resection.
Impact:
- Highlights the rising incidence of MPLC, suggesting improved detection methods.
- Underscores the need for revised diagnostic and surgical approaches for peripheral small adenocarcinomas and MPLC.
- Emphasizes the importance of HRCT in identifying MPLC and guiding patient management.
