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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
[Pathohistologic diagnosis of cholesterol ester storage disease]
M Zlatkovic1, I Stankovic, D Prokic
1Department of Pathology, Dr. Vukan Chupitsh Mother and Child Health Institute, Belgrade.
Abstract:
Cholesteryl ester storage disease (CESD) is rare and characterised by accumulation of cholesteryl esters and triglycerides in many tissues due to the deficiency of lysosomal acid lipase. We report on a 2 1/2-year old child with CESD. The diagnosis was made by liver biopsy and finding of heat-sensitive birefrigent crystals seen in frozen liver tissue under polarized light. In world literature the number of cases previously described is small (in paediatric age group does not exceed 40), and this was the reason for the presentation of our patient.
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