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[Relationship between circulating vascular cell adhesion molecule-1 and vascular complications in type 2 diabetes
1Department of Endocrinology, The Second Affilliated Hospital, Medical College, Zhejiang University, Hangzhou 310009, China.
Objective:
To investigate the relationship between soluble vascular cell adhesion molecule-1 (sVCAM-1) and type 2 diabetes complicated with vascular diseases.
Methods:
In 61 cases of type 2 diabetes with macrovascular or microvascular complications and 36 cases of healthy control, sVCAM-1 levels were measured in duplicate by enzyme-linked immunosorbent assay using the soluble VCAM-1 Kit (R& D Systems Ltd, Ablingdon, Oxfordshire, UK).
Results:
sVCAM-1 levels in type 2 diabetes [(973.25 +/- 73.38) microg/L] were higher than these of healthy controls [(230.45 +/- 12.47) microg/L], P < 0.001. sVCAM-1 levels of type 2 diabetes with hypertension [(1263.99 +/- 87.00) microg/L] were higher than those of type 2 diabetes with microvascular complications [(726.57 +/- 95.40) microg/L], P < 0.001.
Conclusion:
There was a significant correlation between sVCAM-1 concentration and vascular complications of type 2 diabetes.
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