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Aip1p Dynamics Are Altered by the R256H Mutation in Actin
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The actin-depolymerizing factor destrin has an actin-stabilizing domain

K Tokuraku1, S Okamoto, M Katsuki

  • 1Department of Chemical Science and Engineering, Miyakonojo National College of Technology, Miyazaki, Japan. tokuraku@miyakonojo-nct.ac.jp

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|January 22, 2002
PubMed

Keywords:
actin regulationdestrin proteincytoskeletal dynamicsactin filament stabilization

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Actin is a highly conserved cytoskeletal protein found abundantly in eukaryotic cells. It constitutes 10% weight of the total cellular protein in muscle cells, while in non-muscle cells, it is lower and makes up around 1–5 percent of the total cell protein. Actin found in the unicellular amoebae and complex multicellular animals is around 80% similar, demonstrating their conservation over a billion years of evolution.  Actin coding genes are conserved within species and across different species.
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