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Pigmented epidermal cysts.

T Shet1, S Desai

  • 1Department of Pathology, T. N. Medical College & B. Y. L. Nair Ch. Hospital, Mumbai Central, Mumbai, India.

The American Journal of Dermatopathology
|January 22, 2002
PubMed
Summary
This summary is machine-generated.

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Melanin pigment and melanocytes are present in most epidermal cysts, particularly in Indian patients. Pigmentation patterns in these skin cysts depend on anatomy and skin color, not hemochromatosis.

Area of Science:

  • Dermatopathology
  • Histology
  • Pigment Biology

Background:

  • Limited documentation exists on melanin or melanocytes within epidermal cysts.
  • Understanding pigment presence in epidermal cysts is crucial for accurate diagnosis.

Purpose of the Study:

  • To investigate the prevalence and distribution of melanin pigment and melanocytes in epidermal cysts.
  • To determine the relationship between cyst location, skin color, and pigmentation.
  • To clarify the cause of extensive pigment accumulation in some epidermal cysts.

Main Methods:

  • Analysis of 125 epidermal cysts from Indian patients.
  • Utilized Masson's Fontana stain for melanin detection.
  • Employed immunohistochemistry for S-100 protein and HMB 45 to identify melanocytes.

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Main Results:

  • Melanin pigment or melanocytes were observed in 79 (63%) of the analyzed epidermal cysts.
  • Pigmentation was absent in cysts from embryogenic fusion lines and distal extremities.
  • Extensive melanin accumulation occurred in 10 cysts, often associated with melanophages and prior trauma.

Conclusions:

  • Epidermal cyst pigmentation exhibits a distinct anatomical pattern influenced by natural skin color.
  • Significant pigment accumulation is linked to cyst rupture, not hemochromatosis.
  • Melanocytes and melanin are common findings in epidermal cysts, with specific distribution patterns.