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[Adrenomedullin and hypoxia-induced pulmonary hypertension]
1Department of Respiratory Medicine, Beijing General Hospital of PLA, Beijing 100700, China.
Objective:
To study adrenomedullin (AM) in rat and human lung during hypoxia-induced pulmonary hypertension.
Methods:
Normobaric hypoxic pulmonary hypertension animal model was adopted, pulmonary artery pressure and RVdp/dt were measured. The changes of AM contents in blood and bronchoalveolar lavage fluid were studied. The plasma levels of AM in patients with pulmonary hypertension were measured.
Results:
During hypoxia, pulmonary artery pressure, RVdp/dt, AM contents in blood and bronchoalveolar lavage fluid in rats increased. Plasma levels of AM were significantly higher in patients with pulmonary hypertension than in the control subjects.
Conclusions:
AM may play an important role in developing hypoxic pulmonary hypertension in rats and human. The increase of AM level is in proportion to the extent of pulmonary hypertension.