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Inulin as filler-binder for tablets prepared by direct compaction
Anko C Eissens1, Gerad K Bolhuis, Wouter L J Hinrichs
1Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. A.C.Eissens@farm.rug.nl
Summary
Amorphous inulin with entrapped air exhibits favorable tabletting properties, acting as a viable alternative to conventional excipients. Its lubricant sensitivity and dissolution characteristics depend on particle properties and chain length.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Amorphous inulin is a potential pharmaceutical excipient.
- Understanding its tabletting properties is crucial for formulation development.
Purpose of the Study:
- To investigate the tabletting properties of various amorphous inulin types.
- To correlate these properties with chain length, particle size, and entrapped air content.
Main Methods:
- Evaluation of powder flow and density.
- Compactibility assessment using a compaction simulator.
- Analysis of lubricant sensitivity and tablet disintegration/dissolution.
Main Results:
- Improved powder flow with increased particle size.
- High bonding capacity across all inulin types.
- Lubricant sensitivity varied, being high for inulins with low entrapped air and low for those with high entrapped air.
- Tablets dissolved rather than disintegrated, with dissolution time inversely related to chain length.
Conclusions:
- Amorphous inulin with significant entrapped air demonstrates good filler-binder capabilities.
- Inulin's properties suggest it as an attractive alternative to common pharmaceutical excipients.
- Chain length influences dissolution, offering potential for specific dosage forms like chewable tablets.