Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

AEXpulsing a retrograde signal.

Michael L Nonet1

  • 1Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

Neuron
|January 24, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A single component landing site for efficient transgenesis using recombination-mediated insertion.

microPublication biology·2025
Same author

Parameters that influence bipartite reporter system expression in Caenorhabditis elegans.

Genetics·2025
Same author

F-box protein FBXB-65 regulates anterograde transport of the kinesin-3 motor UNC-104 through a PTM near its cargo-binding PH domain.

Journal of cell science·2024
Same author

Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling.

PLoS genetics·2023
Same author

UNC-49 is a redox-sensitive GABA<sub>A</sub> receptor that regulates the mitochondrial unfolded protein response cell nonautonomously.

Science advances·2023
Same author

Rapid generation of Caenorhabditis elegans single-copy transgenes combining recombination-mediated cassette exchange and drug selection.

Genetics·2023
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
Same journal

Microglial fitness in moderation: Tuning TREM2 signaling through Ptpn6.

Neuron·2026
See all related articles

Researchers identified AEX-1 as a key protein regulating the release of retrograde signals from muscle cells. This finding advances our understanding of synaptic development and plasticity.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Synaptic Plasticity

Background:

  • Secreted retrograde signals are crucial for synaptic development, maintenance, and plasticity.
  • Mechanisms governing the release of these signals remain largely unknown.

Discussion:

  • Doi and Iwasaki identify AEX-1, a protein related to the UNC-13/Munc13 family, as a potential regulator of retrograde signal release.
  • The study implicates AEX-1 in the machinery responsible for releasing these signals from muscle cells.

Key Insights:

  • AEX-1 is proposed as a novel candidate for controlling the release of retrograde signaling molecules.
  • This research sheds light on the molecular underpinnings of retrograde signaling in the nervous system.

Outlook:

Related Experiment Videos

  • Further investigation into AEX-1's precise role could reveal new therapeutic targets for neurological disorders.
  • Understanding AEX-1's function may provide insights into muscle-to-neuron communication pathways.