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Related Experiment Videos

Glutamine promotes triglyceride absorption in a dose-dependent manner.

Jeffrey B Schwimmer1, Looi Ee, Shuqin Zheng

  • 1Division of Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.

American Journal of Physiology. Gastrointestinal and Liver Physiology
|January 24, 2002
PubMed
Summary

Dietary L-glutamine (L-Gln) supplementation with lipid meals can significantly impact triglyceride absorption in rats. This amino acid specifically influences lymphatic fat transport in a dose-dependent manner.

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Area of Science:

  • Nutrition Science
  • Gastroenterology
  • Metabolism

Background:

  • Dietary proteins influence lipid absorption, but the specific role of amino acids remains unclear.
  • Investigating the impact of amino acids on nutrient absorption is crucial for understanding metabolic processes.

Purpose of the Study:

  • To determine if enterally administered L-glutamine (L-Gln) enhances triglyceride (TG) absorption when given with a lipid meal in rats.
  • To explore the dose-dependent effects and specificity of L-Gln on lymphatic fat transport.

Main Methods:

  • Adult male Sprague-Dawley rats with mesenteric lymph fistulae and gastroduodenal feeding tubes were used.
  • Rats received a lipid meal followed by enteral infusions of varying L-Gln concentrations (0-340 mM), D-Gln, or an amino acid mixture.

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  • Lymph was collected for 6 hours and analyzed for triglyceride content.

    • Main Results:

    • Infusion of 85 mM L-Gln increased total TG output by 64% compared to controls (P < 0.05) without altering lymph flow.
    • Infusion of 340 mM L-Gln decreased total TG output by 43% compared to controls (P < 0.05).
    • The observed effects were specific to L-Gln, as D-Gln and an amino acid mixture did not elicit similar responses.

    Conclusions:

    • L-glutamine (L-Gln) specifically modulates lymphatic triglyceride transport in a dose-dependent manner.
    • Low doses of L-Gln promote fat absorption, while high doses impair it.
    • These findings highlight the complex role of L-Gln in lipid metabolism and lymphatic transport.